CSE Seminar
SPEAKER: Jane Valentine,
Department of Biomedical Engineering,
Carnegie Mellon University
TITLE:
Optimization of Biochemical Sensors and Sensor Arrays
DATE: Monday, April 28, 2008
TIME: 12:00 Noon
PLACE: 2240 DCL
1304 W. Springfield Ave., Urbana, IL
ABSTRACT
Acoustic wave biochemical sensors work by detecting the frequency
shifts resulting from the binding of target molecules to a
functionalized resonator. We describe our work on a
Micro-Electro-Mechanical Systems (MEMS) based acoustic wave biochemical
sensor using a membrane resonator. Due to a high surface area to mass
ratio, we believe a membrane resonator may allow for increased
sensitivity relative to other resonator structures. We demonstrate the
effects of spatial distributions of mass on the membrane on sensitivity
and show how to use this spatial sensitivity to detect multiple targets
simultaneously. To do so we simulate the membrane response to
spatially uneven mass loadings using a finite element package, and
independently derive a function approximating the membrane response
surface to spatial mass loadings under the applicable range of
conditions. We verify the agreement between our simulation and model,
and present sensitivity calculations demonstrating the advantages of
variable mass loadings. We then use our reduced-order model of the
membrane response surface as a basis for optimization of multi-target
detection systems using only a single membrane, optimizing for multiple
objective functions, including discrimination and sensitivity.